I gave this presentation at BriForum 2007 last year in Chicago.  It discusses both the technical aspects of sequencing applications as well as tips ways to optimize the process of mass-sequencing efforts.

This presentation, along with the entire 3-day conference, is available on DVD on the BriForum site .  However, you can download my PowerPoint presentation below. 

Download: SoftGrid Advanced Sequencing: BriForum 2007 (1.7 MB)